This thread on the FutureQuest support site shows the way one leading highly efficient and technically very able and agile host is thinking atm about blocklists. Interesting reading...

I'd be interested in reaction

Just goes to show you there's only one reliable way to stop spam:

Shutdown the source.

Ignoring the problem won't make it go away, just encourages spammers to dream up even more ways to get around the filtering.

Yepper, shut down the source..., report them all.